◀ Back to PIK3R1
LYN — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG Chemokine signaling pathway:
CSK/FGR/HCK/LYN
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database Fc-epsilon receptor I signaling in mast cells:
Antigen/IgE/Fc epsilon R1/LYN/SYK complex (IGHE-SYK-LYN-MS4A2-FCER1G-FCER1A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Manetz et al., Mol Cell Biol 2001, Barker et al., Mol Biol Cell 1995
Evidence: assay, other species
-
NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit):
LYN (LYN)
→
PI3K complex (PIK3CA-PIK3R1)
(cell migration, collaborate)
Price et al., Biochem Biophys Res Commun 1999*
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Marshall et al., J Exp Med 2000, Anderson et al., Curr Biol 2000
Evidence: assay, physical interaction
-
Reactome Reaction:
LYN
→
PIK3R1
(reaction)
Sun et al., J Biol Chem 2008
-
Reactome Reaction:
LYN
→
PIK3R1
(indirect_complex)
Sun et al., J Biol Chem 2008
-
WikiPathways Chemokine signaling pathway:
CSK/FGR/HCK/LYN
→
PIK3CA/PIK3CD/PIK3R1/PIK3R2/PIK3R3/PIK3CG/PIK3R5/PIK3CB
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Qin et al., Biochemistry 2003
:
Under our conditions, hydrogen peroxide induced
PI3K and Akt activation was
independent of
Lyn , Syk, Cbl, BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Xu et al., Immunol Cell Biol 2012
:
Regulating SFK activity may thus be a central mechanism by which
Lyn regulates
PI3K activity in B cells