Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — PIK3R1

Text-mined interactions from Literome

Lin et al., J Biol Chem 2003 : Phosphatidylinositol 3-kinase , protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
Gingery et al., J Cell Biochem 2003 (MAP Kinase Signaling System) : PI3K inhibition also blocked MEK1/2 , ERK1/2, and AKT phosphorylation and NFkappaB activation in purified osteoclasts
Levinthal et al., J Biol Chem 2004 : Furthermore, we show that transient PI3K inhibition prevents the delayed activation of MEK-1 , a direct activator of ERK, during oxidative stress
Duca et al., Mol Pharmacol 2005 : The simultaneous inhibition of PKA and PI3K , by N- ( 2- ( p-bromocinnamylamino ) ethyl ) -5-isoquinolinesulfonamide ( H89 ) and 2- ( 4-morpholynil ) -8-phenyl-4H-1-bemzopyran-4-one ( LY294002 ), respectively, blocked MEK1/2 and ERK1/2 phosphorylation, as did lactose, an EBP antagonist
Merino et al., Nephrol Dial Transplant 2008 (Kidney Diseases) : This inflammatory response was mediated by intracellular signalling dependent on NF-kappaB, p38 MARK or c-Jun PI3K but not by MEK1/2 activation
Choi et al., Stem Cells Dev 2008 (MAP Kinase Signaling System) : Moreover, the pERK1/2 and pAkt upregulation induced by FGF-2 and -4 were completely abolished by treatment with the MEK1/2 inhibitor, U0126 and the PI3K inhibitor , LY294002
Yang et al., Eur J Pharmacol 2010 : These results suggest that plumbagin activates NAD ( P ) H oxidase, Src, and PI3K, and that the activated PI3K or PDK1 subsequently stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells
Lasala et al., Am J Physiol Endocrinol Metab 2011 : Blocking PKA abolished the effect of cAMP on Sox9, Sf1, and Gata4 expression, inhibiting PI3K/PKB impaired the effect on Sf1 and Gata4, and reducing MEK1/2 and p38 MAPK activities curtailed Gata4 increase
Chang et al., Gen Comp Endocrinol 2012 : The specific inhibitors of either MEK1 ( U-0126 and PD-98059 ), JAK ( AG-490 ), JNK ( SP-600125 ), or PI3K ( LY-294002 and wortmannin ) reduced ET-1 increased levels of SOCS-3 mRNA and respectively inhibited ET-1 stimulated activities of MEK1 , JAK, JNK, and PI3K