◀ Back to AKT3
AKT3 — MAP3K5
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kim et al., Mol Cell Biol 2001
:
Akt phosphorylates and negatively
regulates apoptosis signal regulating kinase 1
Ling et al., Biochem J 2004
(Inflammation) :
The suppressive effects of HC-gp39 were dependent on phosphoinositide 3-kinase activity, and treatment of cells with HC-gp39 resulted in
AKT mediated serine/threonine phosphorylation of
apoptosis signal regulating kinase 1
Yang et al., Cell Microbiol 2006
(MAP Kinase Signaling System) :
Furthermore, the inhibition of
PI3K-Akt , but not ERK 1/2 pathway, attenuated M. tbc
induced S6K1 phosphorylation, whereas PI3K inhibition enhanced p38 phosphorylation and
apoptosis signal regulating kinase 1 activity during exposure to M. tbc
Widenmaier et al., J Biol Chem 2009
:
Suppression of p38 MAPK and JNK via
Akt mediated inhibition of
apoptosis signal regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose dependent insulinotropic polypeptide ... Inhibition of apoptosis by GIP is therefore mediated via a key pathway involving
Akt dependent inhibition of
apoptosis signal regulating kinase 1 , which subsequently prevents the pro-apoptotic actions of p38 MAPK and JNK