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MAPK11 — SLC22A3

Text-mined interactions from Literome

Bhowmick et al., J Biol Chem 2001 : Limiting p38MAPK activity through the expression of a dominant negative-p38MAPK also blocked TGF-beta mediated EMT
Janda et al., J Cell Biol 2002 (Cell Transformation, Neoplastic...) : Using specific inhibitors and effector-specific Ras mutants, we show that a hyperactive Raf/mitogen activated protein kinase ( MAPK ) is required for EMT , whereas activation of phosphatidylinositol 3-kinase (PI3K) causes scattering and protects from TGFbeta induced apoptosis
Bakin et al., J Cell Sci 2002 (Cell Transformation, Neoplastic) : Forced expression of dominant negative ( DN ) MAPK kinase 3 ( MKK3 ) inhibited TGFbeta mediated activation of p38MAPK and EMT
Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Phosphorylation of Smad proteins and/or mitogen activated protein kinases ( MAPK ) is required for TGF-beta1 induced EMT ... Chemical inhibition of ERK but not p38 MAPK inhibited TGF-beta1 induced Smad 2 phosphorylation, and both MAPK inhibitors inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced EMT
Lee et al., J Korean Med Sci 2007 (Fibrosis) : We found that high glucose and H2O2 as well as transforming growth factor-beta1 ( TGF-beta1 ) induced EMT in HPMC and that high glucoseinduced EMT was blocked not only by inhibition of TGF-beta1 but also by antioxidants or inhibitors of mitogen activated protein kinases ( MAPK ) ... Since MAPKs are downstream target molecules of reactive oxygen species ( ROS ), these data suggest that high glucose induced generation of ROS and subsequent MAPK activation mediate high glucose induced EMT in HPMC
Choi et al., Drug News Perspect 2008 (Disease Progression...) : Recent studies indicate that the EMT induced by TMPRSS4 involves activation of extracellular signal regulated kinase ( ERK ) 1/2 and mitogen activated protein kinase ( MAPK )
Lv et al., PloS one 2011 : In this study, the role of p38 MAPK in AP-1 activation and in the EMT in the human proximal tubular epithelial cell line ( HK-2 ) under high glucose concentration conditions is investigated ... This study suggests that p38 MAPK may play an important role in the high glucose induced EMT by activating AP-1 in tubular epithelial cells
Tomlinson et al., PloS one 2012 : MAPK activation regulated migration and E-cadherin expression, indicating that combined activation of PLC? and MAPK is required for a full EMT
Wehbe et al., PloS one 2012 (MAP Kinase Signaling System...) : Inhibition of the mitogen activated protein kinase ( MAPK ) activation pathway in Amela tumor lines leads to reduced expression of EMT hallmark genes and inhibits both proinflammatory cytokine Ccl2 gene expression and Ccl2 production by the melanoma cells
Chen et al., Arch Med Res 2013 (MAP Kinase Signaling System) : The roles of p38 MAPK and JNK in TGF-ß1 mediated EMT were investigated using gene silencing and inhibitor SB-203580 and SP-600125