◀ Back to BCL2

BCL2 — MAPK8

Pathways - manually collected, often from reviews:

• BioCarta hiv-1 nef: negative effector of fas and tnf: JNK1 (MAPK8) → BCL-2 (BCL2) (modification, activates)
• BioCarta keratinocyte differentiation: JNK1 (MAPK8) → BCL-2 (BCL2) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCL2 — MAPK8 (direct interaction, enzymatic study) Kang et al., FEBS Lett 2005*
• IRef Hprd Interaction: BCL2 — MAPK8 (in vivo) Yamamoto et al., Mol Cell Biol 1999*, Huang et al., FASEB J 2002*, Tamura et al., FEBS Lett 2004*
• IRef Innatedb Interaction: MAPK8 — BCL2 (unknown, -) Kang et al., FEBS Lett 2005*
• IRef Intact Interaction: MAPK8 — BCL2 (phosphorylation reaction, experimental interaction detection) Kang et al., FEBS Lett 2005*

Text-mined interactions from Literome

Deng et al., Proc Natl Acad Sci U S A 2000 : A role for a MEK/MAPK as a responsible SRK was implicated because the highly specific MEK/MAPK inhibitor, PD98059, also can only partially inhibit IL-3 induced Bcl2 phosphorylation, whereas the combination of PD98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis
McKean et al., J Immunol 2001 (MAP Kinase Signaling System) : Importantly, when TCR activated thymocytes are simultaneously coengaged by both CD28 and CD2 receptors, CD28 signals can inhibit ERK/MAPK dependent Bcl-2 protein up-regulation
Maa et al., J Allergy Clin Immunol 2003 (Asthma) : An inhibition of MAPK reduced the Bcl-2 expression and increased eosinophil apoptosis in patients with asthma
Sarker et al., J Neurochem 2003 : Interestingly, ebselen also activates p44/42 MAPK , and inhibits the downregulation of the antiapoptotic protein Bcl-2 in SNP treated PC12 cells
Miyoshi et al., Cancer Res 2004 : Involvement of the MAPK activation in the Bcl-2 phosphorylation and apoptosis induction also was observed in HL-60 and HeLa cells
Van Laethem et al., FASEB J 2004 : Furthermore, we show that Bcl-2 overexpression, but not the pan-caspase inhibitor zVAD-fmk, blocks Bax conformational change and its subsequent translocation downstream of p38 MAPK
Qin et al., Free Radic Biol Med 2006 : The effect of apocynin on apoptosis was associated with reduced p38 MAPK activity, increased Bcl-2 protein, and decreased Bax protein and caspase-3 activity
Wang et al., J Mol Cell Cardiol 2006 (Inflammation...) : Following reperfusion, homogenized hearts were analyzed for TNF-alpha, IL-1beta, and IL-6 gene and protein expression, p38 MAPK activation , and the apoptosis related proteins caspase-3 and Bcl-2
Quadros et al., Cancer Biol Ther 2006 (Carcinoma, Squamous Cell) : This effect is due, in part, to sustained MAPK dependent Bcl-xL expression
Alfano et al., J Biol Chem 2006 : Accordingly, incubation of retinal pigment epithelial cells with uPA elicits a time dependent enhancement of MAPK and phosphatidylinositol 3-kinase activities as well as the transcriptional activation of Bcl-xL anti-apoptotic factor
De Chiara et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Furthermore, we obtained evidence that p38 MAPK induced Bcl-2 phosphorylation plays a key role in the early events following serum deprivation in embryonic fibroblasts
Murakami et al., J Biochem 2007 : While the brefeldin A-treatment induced the phosphorylation of both c-Jun N-terminal kinase (JNK) and p38 MAPK , overexpression of Bcl-x ( L ) or Bcl-2 reduced the prolonged phosphorylation of JNK, but not of p38 MAPK
Haddad et al., Protein Pept Lett 2007 (Hypoxia-Ischemia, Brain...) : The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion dependent regulation of MAPK ( ERK ) : discordant proteomic effect of MAPK ( p38 )
Yeo et al., Biochim Biophys Acta 2007 (Brain Injuries...) : Moreover, selenite activates p44/42 MAPK and inhibits the downregulation of Bcl2 in selenite treated NPC cells
Kang et al., J Cell Physiol 2008 (Uterine Cervical Neoplasms) : These results support a notion that ROS mediated activations of p38 MAPK and JNK in response to As2O3 treatment signals activation of Bax and phosphorylation of Bcl-2 , resulting in mitochondrial apoptotic cell death in human cervical cancer cells
Lim et al., J Neurosci Res 2008 : Thus, MAPK/ERK dependent p35 up-regulation and MAPK/ERK dependent and PI3K/Akt dependent Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells
Kang et al., Oncol Rep 2008 (Uterine Cervical Neoplasms) : These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations
Giordano et al., J Neurochem 2009 : In CGNs from both Gclm ( +/+ ) and ( -/- ) mice, carbachol induces a MAPK dependent increase in the level of the anti-apoptotic protein Bcl-2
Nencioni et al., J Biol Chem 2009 : In infected Bcl-2 ( + ) cells, activated p38MAPK was found predominantly in the cytoplasm, colocalized with Bcl-2, and both Bcl-2 phosphorylation and virally induced apoptosis were diminished by specific inhibition of p38MAPK activity
Chen et al., Toxicology 2009 (Neuroblastoma) : SB202190 ( p38 MAPK inhibitor ) and SP600125 ( JNK inhibitor ) attenuated mitochondrial depolarization, degradation of Bcl-2/Bcl-xL , and mitochondrial translocation of Bax ... SB202190 ( p38 MAPK inhibitor ) and SP600125 ( JNK inhibitor ) attenuated mitochondrial depolarization, degradation of Bcl-2/Bcl-xL , and mitochondrial translocation of Bax
Jilaveanu et al., Clin Cancer Res 2009 (Disease Progression...) : C-Raf siRNA knock-down results in decreased viability of YULAC ( B-Raf ( V600K ) ) and YUROB ( B-Raf ( WT ) ) melanoma cells, likely mediated by Bcl-2 inhibition rather than mitogen activated protein kinase inhibition
Chen et al., J Cell Physiol 2010 (Neuroblastoma) : Moreover, phospho-p38 MAPK and phospho-JNK were proved to be involved in Bcl-xL degradation, and overexpression of Bcl-xL attenuated the cytotoxic effect of notexin
Keuling et al., Pigment Cell Melanoma Res 2010 (Melanoma...) : Recently, it was reported that the combination of MAPK pathway inhibition by specific MEK inhibitors and Bcl-2 family inhibition by BH3-mimetic ABT-737 synergistically induces apoptotic cell death in melanoma cell lines
Wang et al., J Mol Neurosci 2011 (MAP Kinase Signaling System) : 17ß-estradiol protects dopaminergic neurons in organotypic slice of mesencephalon by MAPK mediated activation of anti-apoptosis gene BCL2 ... Taken together, MAPK pathway mediated BCL2 expression accounted for one of the key mechanisms involved in E2 neuroprotective effect on dopaminergic neurons against 6-OHDA insult
Peart et al., Rejuvenation Res 2012 (Ischemia...) : CR counters age effects on postischemic dysfunction/cell death ; this is associated with reversal of age effects on p70S6K, augmentation of Akt and Bcl2 levels, and preischemic p38-MAPK activation
Cipak et al., Neoplasma 2012 (Leukemia...) : Inhibitors of JNK ( SP600125 ) and p38 MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax, and blocked down-regulation of Bcl-2 , XIAP and survivin in HEAMQ treated U937 cells
Zhao et al., Brain Res 2013 (Brain Edema...) : In addition, we found SB203580 significantly decreased P-p38 MAPK levels, and inhibited HPC induced mitochondria translocation of Bcl-xL in the brain of HPC and MCAO treated mice
Bai et al., Int J Biochem Cell Biol 2013 : The disruption of mitochondrial outer membrane permeabilisation, the activation of caspase-3/7 and 9, the downregulation of Bcl-2 , the upregulation of Bax, and the activation of p38 MAPK , ERK and NF-?B were all observed in HIV-1 Tat treated RPE cells