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GYS1 — MCL1

Text-mined interactions from Literome

Ding et al., Mol Cell Biol 2007 (Neoplasms) : Here, we report that glycogen synthase kinase 3 ( GSK-3 ) was required for Mcl-1 degradation, and we identified a novel mechanism for proteasome mediated Mcl-1 turnover in which GSK-3beta associates with and phosphorylates Mcl-1 at one consensus motif ( ( 155 ) STDG ( 159 ) SLPS ( 163 ) T ; phosphorylation sites are in italics ), which will lead to the association of Mcl-1 with the E3 ligase beta-TrCP, and beta-TrCP then facilitates the ubiquitination and degradation of phosphorylated Mcl-1
Sharma et al., Mol Pharmacol 2012 (Drug-Induced Liver Injury) : Moreover, JNK and glycogen synthase kinase 3ß activation was significantly attenuated, and Mcl-1 degradation was inhibited in APAP treated MLK3-knockout mice