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MCL1 — PIK3R1
Text-mined interactions from Literome
Kuo et al., Oncogene 2001
:
The involvement of
PI 3-K/Akt dependent up-regulation of
Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6 ... However, the IL-6 induced
Mcl-1 up-regulation was effectively attenuated in the
presence of
PI 3-K inhibitors, LY294002 and wortmannin
Maurer et al., Mol Cell 2006
:
S159 phosphorylation of
MCL-1 was
induced by IL-3 withdrawal or
PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1
Saffar et al., J Allergy Clin Immunol 2008
:
Phosphatidylinositol 3-kinase and p38 mitogen activated protein kinase
regulate induction of
Mcl-1 and survival in glucocorticoid treated human neutrophils
Rajalingam et al., PloS one 2008
(Chlamydia Infections...) :
Infection leads to the Raf/MEK/ERK mediated up-regulation and
PI3K dependent stabilization of the anti-apoptotic Bcl-2 family member
Mcl-1
Jiang et al., J Hepatol 2009
:
The JAK/STAT- and
PI3K/Akt dependent pathways, NF-kappaB activation and expression of the anti-apoptotic proteins
Mcl-1 and A1 were evaluated
Faber et al., Proc Natl Acad Sci U S A 2009
(Breast Neoplasms...) :
PI3K inhibition
led to down-regulation of
Mcl-1 , and MEK inhibition led to up-regulation of BIM
Chan et al., J Immunol 2010
:
PI3K dependent upregulation of
Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short lived monocytes ... Temporal transcriptome and protein analyses revealed
Mcl-1 , a member of the Bcl-2 family, was transiently induced in a
PI3K dependent manner during the early stages of HCMV infection ... Overall, our data indicates that activation of the epidermal growth factor receptor/PI3K signaling pathway, via the
PI3K dependent upregulation of
Mcl-1 , is required to circumvent apoptosis in naturally short lived monocytes during the early stages of HCMV infection, thus ensuring the early steps in the viral persistence strategy
Huber et al., PloS one 2013
:
For example, DTX1 activates the
RTK/PI3K/PKB and the MAPK/ERK mitotic pathways and
induces anti-apoptotic
Mcl-1