Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

MCL1 — PIK3R1

Text-mined interactions from Literome

Kuo et al., Oncogene 2001 : The involvement of PI 3-K/Akt dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6 ... However, the IL-6 induced Mcl-1 up-regulation was effectively attenuated in the presence of PI 3-K inhibitors, LY294002 and wortmannin
Maurer et al., Mol Cell 2006 : S159 phosphorylation of MCL-1 was induced by IL-3 withdrawal or PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1
Saffar et al., J Allergy Clin Immunol 2008 : Phosphatidylinositol 3-kinase and p38 mitogen activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid treated human neutrophils
Rajalingam et al., PloS one 2008 (Chlamydia Infections...) : Infection leads to the Raf/MEK/ERK mediated up-regulation and PI3K dependent stabilization of the anti-apoptotic Bcl-2 family member Mcl-1
Jiang et al., J Hepatol 2009 : The JAK/STAT- and PI3K/Akt dependent pathways, NF-kappaB activation and expression of the anti-apoptotic proteins Mcl-1 and A1 were evaluated
Faber et al., Proc Natl Acad Sci U S A 2009 (Breast Neoplasms...) : PI3K inhibition led to down-regulation of Mcl-1 , and MEK inhibition led to up-regulation of BIM
Chan et al., J Immunol 2010 : PI3K dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short lived monocytes ... Temporal transcriptome and protein analyses revealed Mcl-1 , a member of the Bcl-2 family, was transiently induced in a PI3K dependent manner during the early stages of HCMV infection ... Overall, our data indicates that activation of the epidermal growth factor receptor/PI3K signaling pathway, via the PI3K dependent upregulation of Mcl-1 , is required to circumvent apoptosis in naturally short lived monocytes during the early stages of HCMV infection, thus ensuring the early steps in the viral persistence strategy
Huber et al., PloS one 2013 : For example, DTX1 activates the RTK/PI3K/PKB and the MAPK/ERK mitotic pathways and induces anti-apoptotic Mcl-1