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MDM2 — MYLIP

Text-mined interactions from Literome

Kim et al., J Biol Chem 2010 : miR-221 was necessary and sufficient to down-regulate Mdm2 expression, and this down-modulation of Mdm2 by miR-221 prevented the degradation of ( and consequently up-regulated ) the Slug protein, which negatively regulates the proliferation of chondroprogenitors
Li et al., Blood 2013 (Leukemia, Myeloid, Acute) : Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a, HDAC3, KIT, CCND1, and MDM2 directly, and increases PTEN indirectly
Dar et al., J Natl Cancer Inst 2013 (Melanoma...) : The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression
Li et al., Oncotarget 2012 (Glioblastoma...) : Finally, we demonstrated that miR-17 could repress MDM2 levels, resulting in decreased cell proliferation and drug-resistance