Gene interactions and pathways from curated databases and text-mining

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MET — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Petrelli et al., Nature 2002 : Cbl, in turn, binds and ubiquitinates activated HGF receptor , and by recruiting the endophilin-CIN85 complex , it regulates receptor internalization
Taher et al., Biochem Biophys Res Commun 2002 (Arteriosclerosis...) : Stimulation with HGF led to activation of Met as well as to activation of PI3-K , PKB/Akt, MEK, and the MAP kinases Erk1 and -2
Maulik et al., J Cell Mol Med 2002 (Carcinoma, Small Cell...) : We show that association of c-Met with PI3K and GAB2 is diminished by inhibiting c-Met
Watson et al., Neoplasia (New York, N.Y.) 2006 (Adenocarcinoma...) : We conclude that inhibition of c-Met may be a useful therapeutic strategy for EA. Factors other than receptor overexpression, such as c-Met dependent PI3K/Akt signaling, may be predictive of an individual tumor 's response to c-Met inhibition
Martínez-Palacián et al., PloS one 2013 : Altogether, results presented here provide solid evidences that both paracrine and autocrine HGF/Met signaling requires PI3K to promote mouse hepatic oval cell survival against TGF-ß induced oxidative stress and apoptosis