Gene interactions and pathways from curated databases and text-mining

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MIF — SETD2

Text-mined interactions from Literome

Baugh et al., Biochem Biophys Res Commun 2006 : Dual regulation of macrophage migration inhibitory factor ( MIF ) expression in hypoxia by CREB and HIF-1
Oda et al., PloS one 2008 : The effect of MIF on HIF-1 activity was investigated in human breast cancer MCF-7 and MDA-MB-231 cells, and osteosarcoma Saos-2 cells ... We also indicate that the MIF receptor CD74 is involved in HIF-1 activation by MIF at least when MIF is administrated extracellularly ... MIF regulates HIF-1 activity in a p53 dependent manner
Gaber et al., J Immunol 2011 (Anoxia) : In this article, we show that hypoxia, and specifically HIF-1 , is a potent and rapid inducer of MIF expression in primary human CD4 ( + ) T cells, as well as in Jurkat T cells ... MIF signaling via CD74, in turn, is essential for hypoxia mediated HIF-1a expression and HIF-1 target gene induction involving ERK/mammalian target of rapamycin activity complemented by PI3K activation upon mitogen stimulation ... Based on these data, we suggest that hypoxia significantly affects the expression of HIF-1a in a MIF dependent manner leading to a positive-feedback loop in primary human CD4 ( + ) T cells, thus influencing the lymphoproliferative response and DEX action via the GC receptor
Kurihara et al., J Cell Biol 2011 : Conversely, HIF-1a regulated macrophage migration inhibitory factor and promoted macrophage infiltration that accelerates hyaloidal vessel regression