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MIF — SETD2
Text-mined interactions from Literome
Baugh et al., Biochem Biophys Res Commun 2006
:
Dual
regulation of
macrophage migration inhibitory factor ( MIF ) expression in hypoxia by CREB and
HIF-1
Oda et al., PloS one 2008
:
The
effect of
MIF on
HIF-1 activity was investigated in human breast cancer MCF-7 and MDA-MB-231 cells, and osteosarcoma Saos-2 cells ... We also indicate that the MIF receptor CD74 is involved in
HIF-1 activation by
MIF at least when MIF is administrated extracellularly ...
MIF regulates
HIF-1 activity in a p53 dependent manner
Gaber et al., J Immunol 2011
(Anoxia) :
In this article, we show that hypoxia, and specifically
HIF-1 , is a potent and rapid
inducer of
MIF expression in primary human CD4 ( + ) T cells, as well as in Jurkat T cells ...
MIF signaling via CD74, in turn, is
essential for hypoxia mediated HIF-1a expression and
HIF-1 target gene induction involving ERK/mammalian target of rapamycin activity complemented by PI3K activation upon mitogen stimulation ... Based on these data, we suggest that hypoxia significantly affects the expression of
HIF-1a in a
MIF dependent manner leading to a positive-feedback loop in primary human CD4 ( + ) T cells, thus influencing the lymphoproliferative response and DEX action via the GC receptor
Kurihara et al., J Cell Biol 2011
:
Conversely,
HIF-1a regulated
macrophage migration inhibitory factor and promoted macrophage infiltration that accelerates hyaloidal vessel regression