Saito et al., Pigment Cell Res 2003
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Expression of MITF-M is under the regulation of the melanocyte-specific promoter ( M promoter ) of the MITF gene, and transcription from the M promoter is induced by Wnt signals through a nuclear mediator, lymphoid enhancing factor 1 (LEF-1)
Westenskow et al., Development 2009
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We conclude that Wnt/beta-catenin signaling is required for differentiation of the RPE by directly regulating the expression of Mitf and Otx2