Gene interactions and pathways from curated databases and text-mining

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MMP12 — MMP13

Text-mined interactions from Literome

Ala-Aho et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : The enhanced invasion capacity of MMP-13 expressing HT-1080 cells was dependent on MMP activity, as it was blocked by MMP inhibitor Batimastat ( BB-94 ) and tissue inhibitor of metalloproteinases-3 ( TIMP-3 )
Tan et al., Am J Respir Cell Mol Biol 2006 (Pneumonia...) : No increases in RNA levels of MMP-2, MMP-9 , or MMP-8 were found, but levels of MMP-7, MMP-12 , and MMP-13 RNA did increase at 14 d
Higashiyama et al., Hepatology 2007 (Liver Cirrhosis...) : Whereas MMP-13 was transiently expressed mainly in the cells clustering in the periportal areas, MMP-9 expression and enzymatic activity were detected over the resolution process in several different kinds of cells located in the portal areas and along the fibrous septa
Madala et al., J Immunol 2010 (Fibrosis...) : Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12 , MMP13 expression was highly dependent on IL-13 and type II-IL-4 receptor signaling
Kim et al., Rheumatol Int 2012 (Arthritis, Rheumatoid...) : In conclusion, MMP-9 and uPA might be involved in the activation of pro-MMP-13 through unknown mechanisms in arthritic diseases
Li et al., PloS one 2012 (Disease Models, Animal...) : Similar results were observed in the study using MMP408 , a pharmacological inhibitor of MMP-12
Swamydas et al., Cell Adh Migr 2013 (Mammary Neoplasms, Animal...) : Additionally, the addition of specific MMP9/MMP13 and MMP14 inhibitors prevented the MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9