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MMP12 — MMP13
Text-mined interactions from Literome
Ala-Aho et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
The enhanced invasion capacity of
MMP-13 expressing HT-1080 cells was
dependent on
MMP activity, as it was blocked by MMP inhibitor Batimastat ( BB-94 ) and tissue inhibitor of metalloproteinases-3 ( TIMP-3 )
Tan et al., Am J Respir Cell Mol Biol 2006
(Pneumonia...) :
No increases in RNA levels of MMP-2,
MMP-9 , or MMP-8 were found, but levels of MMP-7,
MMP-12 , and MMP-13 RNA did
increase at 14 d
Higashiyama et al., Hepatology 2007
(Liver Cirrhosis...) :
Whereas
MMP-13 was transiently expressed mainly in the cells clustering in the periportal areas,
MMP-9 expression and enzymatic activity were
detected over the resolution process in several different kinds of cells located in the portal areas and along the fibrous septa
Madala et al., J Immunol 2010
(Fibrosis...) :
Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like
MMP12 ,
MMP13 expression was highly
dependent on IL-13 and type II-IL-4 receptor signaling
Kim et al., Rheumatol Int 2012
(Arthritis, Rheumatoid...) :
In conclusion,
MMP-9 and uPA might be
involved in the activation of
pro-MMP-13 through unknown mechanisms in arthritic diseases
Li et al., PloS one 2012
(Disease Models, Animal...) :
Similar results were observed in the study using
MMP408 , a pharmacological
inhibitor of
MMP-12
Swamydas et al., Cell Adh Migr 2013
(Mammary Neoplasms, Animal...) :
Additionally, the addition of specific
MMP9/MMP13 and MMP14 inhibitors
prevented the
MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9