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MMP2 — PIK3R1
Text-mined interactions from Literome
Steinle et al., Auton Neurosci 2003
:
NGF increased choroidal endothelial cell migration by 50 % over control and this was inhibited by pretreatment with LY294002 (
PI3K inhibitor ), Akt inhibitor, and
MMP2/9 inhibitor
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Kuo et al., J Cell Physiol 2006
(MAP Kinase Signaling System) :
Our data showed that extracellular signal regulated kinase ( ERK ) pathway inhibitor PD98059, but not the c-Jun N-terminal kinase (JNK) inhibitor SP600125, p38 kinase inhibitor SB203580, and
PI3K inhibitor wortmannin,
attenuated Src induced
MMP-2 promoter activity
Redondo-Muñoz et al., Blood 2006
(Leukemia, B-Cell...) :
Moreover, B-CLL cells formed podosomes upon adhesion to FN-H89, VCAM-1, or fibronectin
; MMP-9 localized to podosomes in a
PI3-K dependent manner and degraded a fibronectin/gelatin matrix
Hsieh et al., J Rheumatol 2007
(Osteoarthritis, Knee) :
Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the
effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and
PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1,
MMP-2 , and MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Roztocil et al., J Surg Res 2007
:
Migration assays were performed in the presence of K with and without the plasmin inhibitors ( aprotinin and -aminocaproic acid ), the Galphai inhibitor Pertussis toxin, the
MMP inhibitor ( GM6001 ), the
PI3-K inhibitors , Wortmannin and LY294002, and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor )
Lee et al., FEBS Lett 2007
:
The enhanced
MMP-2 activity was significantly
attenuated not only by a
PI3K inhibitor but also by an Akt inhibitor
Zhang et al., Int J Gynecol Cancer 2009
(Carcinoma...) :
Interestingly, the mitogen activated protein kinase or extracellular signal regulated kinase inhibitors PD98059 and U0126 actually increased MMP-2 mRNA and protein synthesis, whereas the
PI3-K inhibitors LY294002 and wortmannin further
suppressed the expression of
MMP-2
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Seo et al., PloS one 2013
:
MS-enhanced
MMP-2 expression and activity were
inhibited by molecular inhibition of Akt using Akt siRNA as well as by
PI3K/Akt inhibitors, LY293002 and AI, but not by MAPK inhibitors such as PD98059, SP600125 and SB203580