Gene interactions and pathways from curated databases and text-mining

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MMP7 — PIK3R1

Text-mined interactions from Literome

Fukaya et al., Oncol Rep 2005 (Lung Neoplasms...) : Inhibition of PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt, resulted in suppression of MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Redondo-Muñoz et al., Blood 2006 (Leukemia, B-Cell...) : Moreover, B-CLL cells formed podosomes upon adhesion to FN-H89, VCAM-1, or fibronectin ; MMP-9 localized to podosomes in a PI3-K dependent manner and degraded a fibronectin/gelatin matrix
Roztocil et al., J Surg Res 2007 : Migration assays were performed in the presence of K with and without the plasmin inhibitors ( aprotinin and -aminocaproic acid ), the Galphai inhibitor Pertussis toxin, the MMP inhibitor ( GM6001 ), the PI3-K inhibitors , Wortmannin and LY294002, and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor )
Kim et al., Biochim Biophys Acta 2010 (Prostatic Neoplasms) : Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated PI3K/AKT activation and posttranslational regulation of MT1-MMP , which may play a role in PC progression
Belo et al., Am J Physiol Gastrointest Liver Physiol 2011 (Colonic Neoplasms...) : Collectively, these findings indicate that ACh induced cell migration is mediated by MMP7 mediated release of HBEGF, an ERBB ligand that activates ERBB1 and downstream ERK and PI3K signaling
Yano et al., Cell communication and signaling : CCS 2012 : PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells