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CAPN7 — MMP9

Text-mined interactions from Literome

Moshal et al., Am J Physiol Heart Circ Physiol 2006 (Hyperhomocysteinemia) : Homocysteine mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC ... Our observations suggested that calpain regulates Hcy induced MMP-9 expression and activity ... Furthermore, studies with pharmacological inhibitors of calpain ( calpeptin and calpain-1 inhibitor ), ERK ( PD-98059 ) and the mitochondrial uncoupler FCCP suggested that calpain and ERK-1/2 are the major events within the Hcy/MMP-9 signal axis and that intramitochondrial oxidative stress regulates MMP-9 via ERK-1/2 signal cascade ... Taken together, these findings determine the novel role of mitochondrial translocation of calpain-1 in MMP-9 activation during HHcy, in part, by increasing mitochondrial oxidative stress
Li et al., Diabetes 2011 (Cardiomyopathy, Hypertrophic...) : In cultured cardiac fibroblasts, high glucose induced proliferation and MMP activities were prevented by calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012 (Aortic Aneurysm, Abdominal...) : Inhibition of calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin, attenuates AngII induced leukocyte infiltration, perivascular inflammation, and MMP activation in mice
Singh et al., Can J Physiol Pharmacol 2012 (Anoxia...) : On the other hand, inhibition of calpain activity upon treatment with leupeptin or MDL 28170 significantly reduced the MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity