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MMP9 — PIK3R1
Text-mined interactions from Literome
Ellerbroek et al., Cancer Res 2001
(MAP Kinase Signaling System...) :
Inhibition of
PI3K and MAPK activity
impairs EGF stimulated cell migration, in vitro invasion, and
MMP-9 production
Yao et al., Oncogene 2001
(Breast Neoplasms...) :
MEK-1 inhibitor PD098059 partially blocked MMP-9 activation, whereas
PI3-K inhibitor wortmannin
had no effect on heregulin-beta1 mediated
MMP-9 activation
O-charoenrat et al., Int J Cancer 2004
(Carcinoma, Squamous Cell...) :
Selective inhibition of ERK/MAPK ( by PD98059 or U0126 ) and
PI3K ( by LY294002 or wortmannin )
led to marked reduction of both basal and BTC induced
MMP-9 activity and invasive ability of HNSCC cells ... Taken together, our data show that BTC
induces MMP-9 production and invasion primarily through activation of EGFR, MAPK and
PI3K/Akt in HNSCC cells
Qiu et al., Reproduction 2004
(MAP Kinase Signaling System) :
Our results suggest that the activation of both
PI3K and MAPK pathways in extravillous trophoblasts is
necessary for the up-regulation of
MMP-9 and TIMP-1 expression by EGF
Wang et al., Shock 2005
(Endotoxemia...) :
The enhanced
MMP-9 levels induced by peptidoglycan was
attenuated by inhibitors of p38 mitogen activated protein kinases ( MAPK ), ( SB202190, 25 microM ) and ERK1/2 ( PD98059, 25 microM ) and inhibitors of Src Tyrosine kinase ( PP2, 5 microM ) and
PI3-K ( LY294002, 25 microM )
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Ko et al., FEBS Lett 2005
:
Our results suggest that PAF induced
MMP-9 expression, in a NF-kappaB dependent manner, is
regulated by Ca ( 2+ ),
PI3K and ERK signaling pathways
Redondo-Muñoz et al., Blood 2006
(Leukemia, B-Cell...) :
Moreover, B-CLL cells formed podosomes upon adhesion to FN-H89, VCAM-1, or fibronectin ;
MMP-9 localized to podosomes in a
PI3-K dependent manner and degraded a fibronectin/gelatin matrix ... Moreover, B-CLL cells formed podosomes upon adhesion to FN-H89, VCAM-1, or fibronectin
; MMP-9 localized to podosomes in a
PI3-K dependent manner and degraded a fibronectin/gelatin matrix
Yoon et al., Mol Cancer Ther 2006
(Breast Neoplasms...) :
H-Ras did not increase
MMP-9 in the
presence of a
PI3K inhibitor, LY294002, and a NF-kappaB inhibitor, SN50
Hsieh et al., J Rheumatol 2007
(Osteoarthritis, Knee) :
Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the
effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and
PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1, MMP-2, and
MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Roztocil et al., J Surg Res 2007
:
Migration assays were performed in the presence of K with and without the plasmin inhibitors ( aprotinin and -aminocaproic acid ), the Galphai inhibitor Pertussis toxin, the
MMP inhibitor ( GM6001 ), the
PI3-K inhibitors , Wortmannin and LY294002, and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor )
Bansal et al., PloS one 2009
:
PIM2 Induced COX-2 and
MMP-9 expression in macrophages
requires PI3K and Notch1 signaling
Kim et al., Exp Mol Med 2009
:
A chemical inhibitor of MEK1/2 or
PI3K reduced phosphorylation of ERK or Akt, respectively, and also
inhibited CSE mediated
MMP-9 induction
Meng et al., Br J Cancer 2009
(Adenocarcinoma...) :
The
PI3K inhibitor, LY294002, further
blocked the expression of
MMP9 and RhoA
Anggakusuma et al., J Dermatol Sci 2010
(Inflammation) :
These results suggest that macelignan protects skin keratinocytes from UVB induced damage and
inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and
PI3K/Akt
Westra et al., BMC musculoskeletal disorders 2010
(Arthritis...) :
THP-1 and SF macrophages produced high levels of VEGF, IL-8, and
MMP-9 , and VEGF protein production was significantly
inhibited by
PI3K-inhibitor , and by both CaMKII inhibitors
Zhao et al., Am J Pathol 2010
(Brain Neoplasms...) :
An EGF receptor (EGFR) kinase inhibitor, a RasN17 dominant negative construct, MEK and
PI3K inhibitors significantly
blocked EGF/EGFR stimulated
MMP-9 , cell invasion, and colony formation in U1242 MG cells, suggesting that MMP-9 is involved in EGFR/Ras/MEK and PI3K/AKT signaling pathway mediated cell invasion and anchorage independent growth in U1242 MG cells
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Zhang et al., J Surg Res 2011
(Aortic Aneurysm, Abdominal...) :
Inhibition of ERK ( UO126 ) or p38 ( SB203580 ), but not
PI3K ( LY294002 or wortmannin ),
blocked AGE induced
MMP-9 expression
Yu et al., Cancer Chemother Pharmacol 2011
(Carcinoma, Non-Small-Cell Lung...) :
The
PI3 K or ERK inhibitors also
attenuated expression of VEGF and
MMP-9
Yen et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
PKA,
PI3K , and ERK inhibitors abolished PGE2- and cAMP induced c-Fos and MMP-9 up-regulation, and ERK activation was
required for the binding of activator protein 1 (AP-1) transcription factor to the
MMP-9 promoter
Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011
:
Thrombin induced Migration and
Matrix Metalloproteinase-9 Expression Are
Regulated by MAPK and
PI3K Pathways in C6 Glioma Cells
Ahmad et al., Mol Cell Endocrinol 2012
:
Studies using chemical inhibitors and siRNAs to signaling molecules showed that
PI3K , Akt, ERK and PKC-? and the transcription factors Elk-1, c-fos and, to a lesser extent, NF-?B are
involved in relaxin 's induction of
MMP-9
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Dilly et al., Int J Cancer 2013
(Neoplasm Invasiveness...) :
Specific inhibitors of 12-LOX,
PI3K or NF-?B
inhibited MMP9 expression in 12-LOX expressing PC-3 cells and resulted in the blockade of the migratory ability of endothelial cells