Gene interactions and pathways from curated databases and text-mining

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MMP9 — PTEN

Text-mined interactions from Literome

Park et al., Cancer Res 2002 (Glioblastoma...) : Ectopic expressions of adenoviral ( Ad ) -wt-PTEN and -lipid phosphatase-deficient ( G129E ) -PTEN , but not both protein and -lipid phosphatase-deficient ( C124S ) -PTEN, reduced MMP-9 secretion and invasion by HA ... These findings strongly suggest the possibility that PTEN may block HA-induced MMP-9 secretion and invasion through its protein phosphatase activity
Moon et al., Arch Biochem Biophys 2004 : PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells ... Expression of PTEN also led to the inhibition of TNF-alpha induced matrix metalloproteinase-9 (MMP-9) expression in VSMC as determined by zymography and immunoblot
Furukawa et al., Int J Oncol 2006 (Brain Neoplasms...) : Ad5CMV-PTEN transfer into the glioma cell lines lacking the wild-type gene product decreased the levels of matrix metalloproteinase (MMP)-2 mRNA and inhibited the enzymatic activities of MMP-2 and MMP-9
Tian et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : On the molecular level, overexpression of PTEN suppressed expression of matrix metalloproteinase (MMP)-2 and -9 in HepG2 cells
Chen et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 : MMP-2/MMP-9 inhibitor III did not obviously affected the expression of PTEN , VEGF or Flk-1 as compared with the non transfected or empty vector transfected cells