Gene interactions and pathways from curated databases and text-mining

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MOK — PIK3R1

Text-mined interactions from Literome

Touré et al., Biochem J 2008 (Ion Channel Gating) : Finally, we found that blocking RAGE with anti-RAGE antibodies or inhibiting PI3K with PI3K inhibitors restored fMLP ( N-formylmethionyl-leucyl-phenylalanine ) -induced neutrophil migration on AGE-collagen
Bianchi et al., J Biol Chem 2011 (Encephalitis) : We show here that high S100B stimulates murine microglia migration in Boyden chambers via RAGE dependent activation of Src kinase, Ras, PI3K , MEK/ERK1/2, RhoA/ROCK, Rac1/JNK/AP-1, Rac1/NF-?B, and, to a lesser extent, p38 MAPK ... The S100B/RAGE dependent activation of diaphanous-1/Rac1/JNK/AP-1, Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines, CCL3, CCL5, and CXCL12, whose release and activity are required for S100B to stimulate microglia migration