Gene interactions and pathways from curated databases and text-mining

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HMOX1 — MSH5

Text-mined interactions from Literome

Kokot et al., Arthritis Rheum 2009 (Disease Models, Animal...) : In addition, alpha-MSH suppressed BLM induced oxidative stress and enhanced the expression of superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1) ... In the BLM mouse model, alpha-MSH reduced skin fibrosis and collagen content and increased tissue levels of SOD2 and HO-1
Kokot et al., Endocrinology 2009 : alpha-MSH alone significantly increased Nrf2 as well as Nrf dependent heme oxygenase-1 , gamma-glutamylcysteine-synthetase, and glutathione-S-transferase Pi gene expression in both keratinocytes and melanocytes