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MSH6 — TCF21
Text-mined interactions from Literome
Ichiyama et al., Brain Res 1999
(Brain Diseases...) :
We examined whether systemic
alpha-MSH and alpha-MSH11-13 inhibit
activation of the nuclear
transcription factor , nuclear factor kappa B (NF-kappaB), a factor that is essential to expression of proinflammatory cytokines, in experimental murine brain inflammation induced by lipopolysaccharide
Kalden et al., Ann N Y Acad Sci 1999
(Inflammation) :
Since many adhesion molecules contain regulatory NF-kappa B sites in their promoter region, the
role of
alpha-MSH in the activation of the
transcription factor NF-alpha B was also investigated
Moustafa et al., J Invest Dermatol 2002
:
We have previously shown that
alpha-MSH can
inhibit tumor necrosis factor-alpha stimulated intercellular adhesion molecule 1 upregulation and nuclear factor kappaB (NFkappaB)
transcription factor activation in melanocyte and melanoma cells
Scholzen et al., Endocrinology 2003
(Vasculitis) :
Likewise,
alpha-MSH effectively
inhibited the
transcription factor nuclear factor-kappaB activation in HDMEC, which is required for CAM gene expression
Sarkar et al., FEBS Lett 2003
(Inflammation) :
alpha-MSH also
inhibited SA-LPS induced nuclear
transcription factor kappaB activation not only in macrophages, but also in a T-cell line and human neutrophils isolated from fresh blood
Lee et al., Br J Dermatol 2007
(Melanoma, Experimental) :
This suggestion was further confirmed by the fact that the increased production levels of microphthalmia associated
transcription factor , tyrosinase and tyrosinase related protein-1
induced by
alpha-MSH were all reduced by DMHF in B16 melanoma cells
Liu et al., Free Radic Biol Med 2012
(Melanoma, Experimental) :
We also found that
a-MSH activated its downstream signal transducer microphthalmia associated
transcription factor ( MITF ) to stimulate Nox4 gene expression
Lee et al., Biol Pharm Bull 2013
:
We also found that SCE decreased
a-MSH induced microphthalmia associated
transcription factor ( MITF ) and tyrosinase expression and induced the activation of extracellular signal regulated kinase ( ERK )
Manna et al., J Immunol 1998
(Glioma...) :
As most types of inflammation require activation of NF-kappa B, we investigated the
effect of
alpha-MSH on the activation of this
transcription factor by a wide variety of inflammatory stimuli