Hobl et al., Clin Exp Rheumatol 2011
(Arthritis, Rheumatoid) :
As little is known about the impact of MTX on other cytokines involved in the pathogenesis of RA, the present trial investigated the effect of MTX on IL-12A and IL-18 gene expression by peripheral blood mononuclear cells ( PBMCs )
Meyer et al., J Rheumatol 1993
(Arthritis, Rheumatoid) :
MTX had no effect on interleukin 1 stimulated production of prostaglandin E, hyaluronic acid and collagenase