Gene interactions and pathways from curated databases and text-mining

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GJA1 — MUC16

Text-mined interactions from Literome

Rivedal et al., Arch Toxicol 2005 : The ability of benzene metabolites to interfere with gap-junction functionality, and especially the dramatic loss of Cx43 induced by MUC , should therefore be considered as a possible mechanism for benzene induced hematotoxicity and development of leukemia
Rivedal et al., Toxicol Appl Pharmacol 2008 : We show that MUC induces cross linking of the gap junction protein connexin43 and that this is likely to be responsible for the induced inhibition of GJIC, as well as the loss of connexin43 observed in Western blots