Gene interactions and pathways from curated databases and text-mining

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IL1A — MYD88

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Medvedev et al., J Immunol 2005 (Bacterial Infections...) : Thus, decreased IL-1 induced association of IRAK-1 and MyD88 with the IL-1RI may result from sequestration of cytoplasmic MyD88 by IRAK-4 mutant proteins
Togbe et al., Lab Invest 2006 : However, the relative roles of the TLR4 adaptor proteins TIRAP and TRIF and of the MyD88 dependent IL-1 and IL-18 receptor pathways in this response are unclear
Rad et al., Gastroenterology 2007 (Gastritis...) : The adaptor protein Myd88 mediates Toll-like receptor ( TLR ), interleukin (IL)-1 , and IL-18 signaling
von Bernuth et al., Science 2008 (Bacterial Infections...) : The MyD88 dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections
Zhou et al., J Virol 2009 (Arenaviridae Infections) : This effect was not the result of MyD88 regulation of IL-1 or IL-18 responses since IL-1R1 KO and IL-18R KO mice were not protected from weight loss
Kissner et al., Innate Immun 2011 (Disease Models, Animal...) : Our results indicated that elevated tumor necrosis factor-a, interferon-?, interleukin (IL)-1a/ß and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was regulated by MyD88
Huang et al., J Immunol 2010 (Inflammation...) : IL-1ß and IL-18 secretion was dependent on inflammasome components pyrin-caspase recruitment domain/apoptotic speck containing protein with a caspase recruitment domain and caspase-1, and the TLR/IL-1R signaling molecule MyD88 was required for inflammatory cytokine synthesis
Ather et al., J Immunol 2011 (Disease Models, Animal...) : Furthermore, SAA drives production of IL-1a, IL-1ß , IL-6, IL-23, and PGE ( 2 ), causes dendritic cell ( DC ) maturation, and requires TLR2, MyD88 , and the NLRP3 inflammasome for secretion of IL-1ß by DCs and macrophages
Shimada et al., PloS one 2011 (Chlamydia Infections...) : In vitro investigation reveals that CP-induced IL-1ß secretion by macrophages requires TLR2/MyD88 and NLRP3/ASC/Caspase-1 signaling
Guerrero et al., Eur J Pharmacol 2012 : Moreover, the joint production of TNF-a, IL-1ß and CXCL1/KC by zymosan was dependent on TLR2/MyD88 signaling
Madera et al., PloS one 2011 : R-848 activation of Toll-like receptor 7/MyD88 dependent signaling in cDCs led to a rapid upregulation of pro-IL-1a and pro-IL-1ß production compared to poly I:C activation of MyD88 independent signaling pathways
Segovia et al., PloS one 2012 (Respiratory Syncytial Virus Infections) : TLR2/MyD88/NF-?B signaling is required for pro-IL-1ß and NLRP3 gene expression during RSV infection
Ouziel et al., Am J Pathol 2012 (Acute Disease...) : Activation of interleukin 1ß (IL-1ß) and immunomodulation via MyD88 , the first signaling molecule in the ST2 pathway, seem to be involved
Kavathas et al., Mucosal Immunol 2013 : In addition, we demonstrate that Ct-induced IL-1ß production and secretion by the trophoblast is independent of TLR2, TLR4, MyD88 , and the Nalp3/ASC inflammasome
Ogura et al., Pathogens and disease 2013 : At higher concentrations, Escherichia coli-type hexa acylated lipid A 506, Salmonella-type hepta acylated lipid A 516, the lipid A precursor lipid IVa and monophosphoryl lipid A induced similar levels of production of the MyD88 dependent cytokine IL-1ß although their potencies varied, whereas the maximum production of the MyD88 independent cytokine RANTES induced by lipid IVa was less than 50 % that of other lipid A compounds
Wesche et al., Immunity 1997 : Thus, MyD88 plays the same role in IL-1 signaling as TRADD and Tube do in TNF and Toll pathways, respectively : it couples a serine/threonine protein kinase to the receptor complex