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MYD88 — PIK3R1
Text-mined interactions from Literome
Rhee et al., J Biol Chem 2006
:
Indeed, we demonstrate that the adaptor molecule
MyD88 associates with TLR5 and silencing MyD88 expression
blocks PI3K activation by disrupting the association between TLR5 and p85
Kuo et al., J Immunol 2006
:
Furthermore, experiments with MyD88 overexpressing fibroblast cells transfected with dominant negative mutants of PI3K demonstrate that class III
PI3K regulates CpG ODN mediated signaling upstream of
MyD88 , while class I PI3K regulation is downstream of MyD88
Shin et al., J Immunol 2009
:
Consistent with this, B. burgdorferi activation of
MyD88 or TLR3/TRIF signaling
resulted in increased activity of
PI3K
Santos-Sierra et al., EMBO J 2009
:
MyD88 is not
essential for
PI3K activation and Akt phosphorylation ; however, cooperates with Mal for PIP ( 3 ) formation and accumulation at the leading edge
Shen et al., Infect Immun 2010
(Listeriosis) :
Moreover, functional activation of
PI3K and Rac1 was
impaired in TLR2 ( -/- ) and
MyD88 ( -/- ) macrophages