Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

MYD88 — PIK3R1

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2006 : Indeed, we demonstrate that the adaptor molecule MyD88 associates with TLR5 and silencing MyD88 expression blocks PI3K activation by disrupting the association between TLR5 and p85
Kuo et al., J Immunol 2006 : Furthermore, experiments with MyD88 overexpressing fibroblast cells transfected with dominant negative mutants of PI3K demonstrate that class III PI3K regulates CpG ODN mediated signaling upstream of MyD88 , while class I PI3K regulation is downstream of MyD88
Shin et al., J Immunol 2009 : Consistent with this, B. burgdorferi activation of MyD88 or TLR3/TRIF signaling resulted in increased activity of PI3K
Santos-Sierra et al., EMBO J 2009 : MyD88 is not essential for PI3K activation and Akt phosphorylation ; however, cooperates with Mal for PIP ( 3 ) formation and accumulation at the leading edge
Shen et al., Infect Immun 2010 (Listeriosis) : Moreover, functional activation of PI3K and Rac1 was impaired in TLR2 ( -/- ) and MyD88 ( -/- ) macrophages