Ganitkevich et al., J Muscle Res Cell Motil 2002
(Calcium Signaling) :
This Ca2+ dependent MLC20 phosphorylation is modulated in a Ca2+ independent manner by inhibiting the constitutive active myosin light chain phosphatase mediated by the monomeric GTPase Rho and the Rho associated kinase as well as protein kinase C or by increasing its activity through cGMP
Fujiwara et al., Circ Res 1988
:
In skinned muscles, Ca2+ ( 0.3-1.0 microM ) increased the force, Vmax and MLC20 phosphorylation, in a dose dependent manner
Makhlouf et al., Cell Signal 1997
:
The initial [ Ca2+ ] i transient in both muscle cell types results in Ca2+/calmodulin dependent activation of MLC kinase, phosphorylation of MLC20 and interaction of actin and myosin