◀ Back to MMP13
MMP13 — MYLIP
Text-mined interactions from Literome
Tardif et al., BMC musculoskeletal disorders 2009
(Osteoarthritis, Knee) :
Regulation of the IGFBP-5 and
MMP-13 genes by the microRNAs miR-140 and
miR-27a in human osteoarthritic chondrocytes ... Transfection with pre-miR-140 significantly decreased ( p = 0.0002 ) and with anti-miR-140 significantly increased ( p = 0.05 ) IGFBP-5 expression at 24 hours, while
pre-miR-27a did not
affect either
MMP-13 or IGFBP-5
Akhtar et al., Arthritis Rheum 2010
(Osteoarthritis) :
Overexpression of
miR-27b suppressed the activity of a reporter construct containing the 3'-UTR of human MMP-13 mRNA and
inhibited the IL-1beta induced expression of
MMP-13 protein in chondrocytes
Stanczyk et al., Arthritis Rheum 2011
(Arthritis, Rheumatoid...) :
Previously, we described increased expression of miR-155 and miR-146a in rheumatoid arthritis ( RA ) and showed a repressive
effect of
miR-155 on
matrix metalloproteinase ( MMP ) expression in RA synovial fibroblasts ( RASFs )
Chiang et al., Biochim Biophys Acta 2013
(Breast Neoplasms...) :
Anti-miR-182 increased the
MMP inhibitor RECK protein in MDA-MB-231 cells while pre-miR-182 reduced RECK protein but not mRNA in normal mammary epithelial H184B5F5/M10 cells
Park et al., Osteoarthritis Cartilage 2013
(Osteoarthritis, Knee) :
Interestingly, IL-1ß induced activation of NF-?B and expression of matrix metalloproteinase (MMP)-1 and
MMP-13 was significantly
inhibited by
miR-558 overexpression
Guo et al., Oncol Rep 2013
:
Furthermore, the overexpression of
miR-708 reduced the expression of Akt1, CCND1,
MMP2 , EZH2, Parp-1 and Bcl2 in A172 and T98G cells
Lin et al., Br J Cancer 2013
(Lung Neoplasms...) :
Anti-miR-92a attenuates
MMP activity, migration and invasion of H1299 cells and STAT3 overexpressing H460 cells, suggesting miR-92a is critical for STAT3 induced invasiveness.Conclusion : The STAT3 induced miR-92a promotes cancer invasion by suppressing RECK and targeting of the STAT3/miR-92a axis may be helpful for cancer treatment
Jin et al., Asian Pac J Cancer Prev 2013
(Bone Neoplasms...) :
This was confirmed by western blotting, which showed that
miR-218 expression
inhibited TIAM1,
MMP2 and MMP9 protein expression