Chen et al., Diabetes 2006
:
Antioxidant N-acetyl-l-cysteine (NAC) prevented mercury induced insulin secretion inhibition and Akt phosphorylation but not increased PI3K activity
Liu et al., Mol Immunol 2008
:
These results suggest that NAC activates mainly PI3K to phosphorylate p65 and subsequently induces DNA binding activity of NF-kappaB, independent of its antioxidative function
Cheung et al., J Cell Biochem 2010
(Colonic Neoplasms) :
The SAA cytotoxicity was blocked by co-incubation with catalase, whereas the SBA cytotoxicity and its subsequent growth arrest were abolished by N-acetyl-L-cysteine (NAC) , but was not affected by PI3K phosphorylation inhibitor LY294002, or catalase, suggesting two separated oxidative stress pathways were mediated by these two ascorbates