Lee et al., Int J Biochem Cell Biol 1997
:
In addition to the activation by Nck5a , Cdk5 is regulated by other mechanisms including additional activator proteins and inhibition by phosphorylation of specific amino acid residues
Tang et al., Prog Cell Cycle Res 1996
:
The mechanism of activation of Cdk5 by Nck5a differs from that of cyclin activation of Cdks in that full Cdk5 kinase activity can be achieved in the absence of phosphorylation of Cdk5