Gene interactions and pathways from curated databases and text-mining

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NFKBIA — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Saleem et al., Oncogene 2004 (Edema...) : We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA induced ( i ) activation of PI3K , ( ii ) phosphorylation of Akt at Thr ( 308 ), ( iii ) activation of NF-kappaB and IKKalpha, and ( iv ) degradation and phosphorylation of IkappaBalpha
Lubin et al., Neuroscience 2005 : Interestingly, inhibition of ERK but not PI3K blocked the kainate mediated increase in phospho-IkappaBalpha
Yang et al., J Biol Chem 2005 : Thus, IFN induces NF-kappaB activation to mediate IFN dependent cell survival signals through a `` canonical '' pathway of IkappaB alpha proteolysis mediated by PI3K/Akt and a `` noncanonical '' pathway of p100 processing mediated by NIK/TRAF
Jana et al., J Immunol 2007 : Involvement of NF-kappaB activation in LPS-, Abeta-, PrP-, poly IC-, Tat-, and MPP+-, but not IFN-gamma-, induced microglial expression of iNOS and stimulation of IkappaBalpha expression and inhibition of NF-kappaB activation by gemfibrozil via the PI3K pathway suggests that gemfibrozil inhibits the activation of NF-kappaB and the expression of proinflammatory molecules in microglia via PI3K mediated up-regulation of IkappaBalpha