◀ Back to PIK3R1
NFKBIA — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Atypical NF-kappaB pathway:
p110-alpha (PIK3CA)
→
I kappa B alpha/PIK3R1 complex (NFKBIA-PIK3R1)
(modification, collaborate)
Kang et al., Mol Cell Biochem 2003, Béraud et al., Proc Natl Acad Sci U S A 1999
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
NF kappa B1 p50/RelA complex (NFKB1-RELA)
→
I kappa B alpha/PIK3R1 complex (NFKBIA-PIK3R1)
(modification, collaborate)
Kang et al., Mol Cell Biochem 2003, Béraud et al., Proc Natl Acad Sci U S A 1999
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
I kappa B alpha/PIK3R1 complex (NFKBIA-PIK3R1)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, collaborate)
Kang et al., Mol Cell Biochem 2003, Béraud et al., Proc Natl Acad Sci U S A 1999
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
I kappa B alpha/PIK3R1 complex (NFKBIA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Kang et al., Mol Cell Biochem 2003, Béraud et al., Proc Natl Acad Sci U S A 1999
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Kang et al., Mol Cell Biochem 2003, Béraud et al., Proc Natl Acad Sci U S A 1999
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
NFKBIA
—
PIK3R1
(direct interaction, pull down)
Béraud et al., Proc Natl Acad Sci U S A 1999
-
IRef Hprd Interaction:
NFKBIA
—
PIK3R1
(in vivo)
Béraud et al., Proc Natl Acad Sci U S A 1999
-
IRef Hprd Interaction:
NFKBIA
—
PIK3R1
(in vitro)
Béraud et al., Proc Natl Acad Sci U S A 1999
-
IRef Intact Interaction:
NFKBIA
—
PIK3R1
(association, competition binding)
Béraud et al., Proc Natl Acad Sci U S A 1999
-
IRef Intact Interaction:
NFKBIA
—
PIK3R1
(association, coimmunoprecipitation)
Béraud et al., Proc Natl Acad Sci U S A 1999
-
IRef Ophid Interaction:
NFKBIA
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Saleem et al., Oncogene 2004
(Edema...) :
We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA induced ( i )
activation of
PI3K , ( ii ) phosphorylation of Akt at Thr ( 308 ), ( iii ) activation of NF-kappaB and IKKalpha, and ( iv ) degradation and phosphorylation of
IkappaBalpha
Lubin et al., Neuroscience 2005
:
Interestingly, inhibition of ERK but not
PI3K blocked the kainate mediated increase in
phospho-IkappaBalpha
Yang et al., J Biol Chem 2005
:
Thus, IFN induces NF-kappaB activation to mediate IFN dependent cell survival signals through a `` canonical '' pathway of
IkappaB alpha proteolysis
mediated by
PI3K/Akt and a `` noncanonical '' pathway of p100 processing mediated by NIK/TRAF
Jana et al., J Immunol 2007
:
Involvement of NF-kappaB activation in LPS-, Abeta-, PrP-, poly IC-, Tat-, and MPP+-, but not IFN-gamma-, induced microglial expression of iNOS and stimulation of IkappaBalpha expression and inhibition of NF-kappaB activation by gemfibrozil via the PI3K pathway suggests that gemfibrozil inhibits the activation of NF-kappaB and the expression of proinflammatory molecules in microglia via
PI3K mediated up-regulation of
IkappaBalpha