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NGF — RAF1

Text-mined interactions from Literome

Söderholm et al., Cell Signal 2001 (Neuroblastoma) : We have now investigated to what extent phorbolester and NGF cause activation of Ras and Raf-1 and the involvement of PKC in this response in differentiating SH-SY5Y/TrkA cells ... NGF stimulated increased accumulation of Ras-GTP and a threefold activation of Raf-1 ... NGF caused a limited increase in phosphorylation of Raf-1 compared with TPA, and NGF induced Raf activity was independent of PKC ... The results identify Raf-1 as a target for both TPA- and NGF induced signals in differentiating SH-SY5Y/TrkA cells and demonstrate that signalling to Raf-1 was mediated via distinct mechanisms
Sánchez et al., Cell Signal 2003 : Involvement in Raf-1 stimulation and NGF induction
Ohmichi et al., J Biol Chem 1992 : NGF dependent activation of raf-1 is not dependent on protein kinase C, since prolonged exposure to phorbol esters under conditions that cause down-regulation of cellular protein kinase C activity has no effect on the NGF response
Vaillancourt et al., Mol Cell Biol 1994 : In response to epidermal growth factor, nerve growth factor , and platelet derived growth factor, B-Raf and Raf-1 are activated, phosphorylate recombinant kinase-inactive MEK-1, and activate wild-type MEK-1