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MAP2K1 — NOS2

Text-mined interactions from Literome

Doi et al., Hypertens Res 2000 : Furthermore, rat iNOS promoter activity using an iNOS-luciferase construct stimulated by cytokines was inhibited by MAPKK-1 inhibition
Chan et al., Infect Immun 2001 : Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK , MKK7-JNK, and NF-kappaB signaling pathways
Chang et al., Arch Toxicol 2001 : These results provide evidence to suggest that exposure to cigarette smoke results in oxidant stress which leads to the stimulation of iNOS and c-fos together with the induction of protein tyrosine phosphorylation and MEK1/ERK2 which in turn may promote lung pathogenesis
Jiang et al., J Biol Chem 2004 : Either PD98059 or U0126, selective inhibitors of MEK, or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- induced ERK activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD
Otero et al., Life Sci 2007 : Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
Da Silva et al., J Biol Chem 1997 : In contrast, PD98059, a specific inhibitor of MEK1 had no effect on iNOS expression