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NOS3 — TP53

Text-mined interactions from Literome

Hsieh et al., Cancer Res 1999 : Resveratrol increases nitric oxide synthase , induces accumulation of p53 and p21 ( WAF1/CIP1 ), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2
Mortensen et al., J Biol Chem 1999 (Breast Neoplasms) : Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53 ... These data point to a previously unrecognized p53 dependent regulation of ecNOS expression that may be important both for regulating apoptosis and for avoiding the generation of genotoxic quantities of NO
de la Monte et al., J Neuropathol Exp Neurol 2007 (Disease Models, Animal...) : Overexpression of NOS3 in the brain increased the levels of APP, APP-Abeta, p53 , Tau, glial fibrillary acidic protein, and peroxisome proliferator activated receptors ( PPAR) delta and gamma and decreased the levels of Hu ( neuronal marker ) mRNA, phosphorylated glycogen synthase kinase 3beta, ATP synthase, and choline acetyltransferase expression as demonstrated by real-time quantitative reverse transcribed polymerase chain reaction, Western blot analysis, or immunohistochemical staining
Blanco et al., Neoplasia (New York, N.Y.) 2007 (Chronic Disease...) : Our results showed DDR pathway activation in preneoplastic lesions, in association with inducible nitric oxide synthase and p53 induction
Rodella et al., Age (Dordrecht, Netherlands) 2013 (Atherosclerosis...) : We demonstrate that SIRT1 and eNOS decresed in APOE mice between 6 and 15 weeks and that aging induced an elevated expression of p53 and ET-1 in APOE animals
Han et al., Atherosclerosis 2012 : Oral administration of THSG for 14 weeks, resulted in notable increases in blood flow in spontaneously hypertensive rats ( SHRs ) ; and effective inhibition of vascular senescence as indicated by senescence associated ß-galactosidase ( SA-ß-gal ) staining, phosphorylation of ?H2AX observed by stain analysis of immunofluorescence, and K373 acetylation of p53 in the aortic arches of SHRs. Oral administration of THSG also induced eNOS expression and urinary NOx production