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NOTCH1 — PIK3R1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bedogni et al., J Clin Invest 2008
(Anoxia...) :
Hyperactivated
PI3K/Akt signaling
led to upregulation of
Notch1 through NF-kappaB activity, while the low oxygen content normally found in skin increased mRNA and protein levels of Notch1 via stabilization of HIF-1alpha
Shepherd et al., Leukemia 2013
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K/mTOR inhibition
upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response