Gene interactions and pathways from curated databases and text-mining

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NOTCH1 — PIK3R1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Bedogni et al., J Clin Invest 2008 (Anoxia...) : Hyperactivated PI3K/Akt signaling led to upregulation of Notch1 through NF-kappaB activity, while the low oxygen content normally found in skin increased mRNA and protein levels of Notch1 via stabilization of HIF-1alpha
Shepherd et al., Leukemia 2013 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response