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NOTCH1 — SIRT1

Text-mined interactions from Literome

Mulligan et al., Mol Cell 2011 : A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
Xie et al., PloS one 2012 (Lung Neoplasms...) : SIRT1 regulates endothelial Notch signaling in lung cancer ... SIRT1 negatively regulates Notch1 intracellular domain (N1IC) and Notch1 target genes HEY1 and HEY2 in response to Delta-like ligand 4 (DLL4) stimulation ... Quantitative chromatin immunoprecipitation ( qChIP ) analysis and gene reporter assay demonstrated that SIRT1 bound to one highly conserved region, which was located at approximately -500 bp upstream of the transcriptional start site of Notch1, and repressed Notch1 transcription