Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — SMAD3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Fu et al., J Biol Chem 2009 : In contrast, Notch increases SMAD3 mRNA expression and protein half-life and regulates the expression of TGFbeta/Smad3 target genes in a gene-specific manner ... Inhibition of Notch in the cardiac cushion of mouse embryonic hearts reduces Smad3 expression ... This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways
Grabias et al., American journal of physiology. Renal physiology 2013 (Fibrosis...) : These divergent patterns of SMAD3 activation are attributed to varying levels of Notch4 dependent phospho-SMAD3 degradation ... Depletion of Notch4 in shear stimulated PTECs eventually increases the levels of active TGF-ß1 protein by approximately fivefold, recovers stable SMAD phosphorylation and ubiquitinated SMAD species, and attenuates collagen accumulation