Gene interactions and pathways from curated databases and text-mining

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NOX1 — PIK3R1

Text-mined interactions from Literome

Yamamori et al., Biochem Biophys Res Commun 2004 : Pharmacological inhibition of PI3K attenuated both fMLP stimulated p47(phox) phosphorylation and NADPH oxidase activity in HL-60 cells differentiated to a neutrophil-like phenotype
Min et al., J Immunol 2005 : It also led to the production of reactive oxygen species via PKC- and PI3K dependent activation of NADPH oxidase in the endothelial cells, and antioxidants suppressed the responses to TRANCE
Bréchard et al., J Leukoc Biol 2009 : In contrast to SOCE inhibition, OAG induced NOX2 activation was mediated by PKC and PI3K
Xia et al., Journal of thrombosis and haemostasis : JTH 2010 : Protein kinase Czeta mediates PI3K regulated NADPH oxidase activation by promoting cellular p47phox translocation
Yang et al., Eur J Pharmacol 2010 : These results suggest that plumbagin activates NAD ( P ) H oxidase , Src, and PI3K, and that the activated PI3K or PDK1 subsequently stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells
Chern et al., Planta Med 2011 (Cerebral Infarction...) : Andrographolide inhibits PI3K/AKT dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Jin et al., Stroke 2011 (Infarction, Middle Cerebral Artery...) : PI3K? deficiency suppressed ischemia/reperfusion induced nuclear factor-?B p65 ( Ser536 ) phosphorylation and the expression of the pro-oxidant enzyme NADPH oxidase ( Nox1, Nox2, and Nox4 ) and proinflammatory adhesion molecules ( E- and P-selectin, intercellular adhesion molecule-1 ) at different time points
Chatterjee et al., Am J Physiol Heart Circ Physiol 2012 (Ischemia) : Activation of NOX2 was greatly diminished by wortmannin, knockout of Akt1, or dominant negative PI3K , whereas membrane depolarization was unaffected
Huang et al., Free Radic Biol Med 2012 (Carcinoma...) : Accordingly, we suggest that PI3K/AKT signaling mediates TGIF induced Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2012 (Colonic Neoplasms) : These responses are related to intracellular reactive oxygen species ( ROS ) generation, NADPH oxidase activation , and upregulation of PI3K/Akt and hypoxia-inducible factor 1 alpha ( HIF-1a ) signaling
Brennan-Minnella et al., Cell death & disease 2013 : The PI3K inhibitor wortmannin prevented NMDA induced NOX2 activation and cell death, without preventing cell swelling, calcium elevation, or mitochondrial depolarization