Gene interactions and pathways from curated databases and text-mining

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CASP3 — NOX4

Text-mined interactions from Literome

Cacicedo et al., Diabetes 2005 (Diabetic Retinopathy) : NAD ( P ) H oxidase appeared to be involved in these responses, since overexpression of dominant negative subunits of NAD ( P ) H oxidase, such as phox47 ( DN ), diminished oxidant stress, and phox67 ( DN ) and N-17 RAC1 ( DN ) prevented the increase in caspase-3 activity
Qin et al., Free Radic Biol Med 2006 : These results suggest that angiotensin II-induced apoptosis is mediated via NADPH oxidase activation probably through p38 MAPK activation, a decrease in Bcl-2 protein, and caspase activation
Ohtsubo et al., Biochem Biophys Res Commun 2008 : Diphenyleneiodonium, an inhibitor of NADPH oxidase , and N-acetylcysteine, a potent antioxidant, also inhibited TNF-alpha induced activation of Mst1 and caspase 3, as well as apoptosis
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : gp91(phox)-NADPH oxidase mediated calpain-1 activation induces caspase-3 activation and TNF-alpha expression in cardiomyocytes during LPS stimulation
Choi et al., Cell Death Differ 2010 (Astrocytoma) : In our experiments, TRAIL ligation induced generation of intracellular ROS through caspase dependent proteolytic activation of PKCdelta and subsequent activation of the NOX4 complex
Aguiló et al., Immunol Cell Biol 2010 : Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase dependent NADPH oxidase activation
Sokolovska et al., Nat Immunol 2013 : Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function