Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — NOX4

Text-mined interactions from Literome

Lynch et al., Br J Pharmacol 1999 : 6 PD 098059 and piceatannol, inhibitors of MAP kinase kinase-1 and the syk tyrosine kinase respectively, had no effect on CD11b/CD18 mediated adhesion or NADPH oxidase activation
Ying et al., FASEB J 2002 (MAP Kinase Signaling System) : PD-098059, a MEK1 inhibitor, and SB-203580, an inhibitor of p38 MAPKalpha-gamma, diminished NOS3 expression and production of TGF-beta1 and NOx