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NOX5 — PAK1

Text-mined interactions from Literome

Schmitz et al., Biochem Biophys Res Commun 2002 : Furthermore, inhibition of Galpha ( i ) by pertussis toxin and inhibition of NADH/NADPH oxidase by diphenylene iodonium also diminished LPA induced stimulation of PAK
Roepstorff et al., J Biol Chem 2008 : We show here in the microglia cell line Ra2 that PAK1 regulates NADPH oxidase ( NOX-2 ) activity in a stimulus-specific manner ... Thus, conditional expression of PAK1 dominant positive mutants enhanced, whereas dominant negative mutants inhibited, NADPH oxidase mediated superoxide generation following formyl-methionyl-leucylphenylalanine or phorbol 12-myristate 13-acetate stimulation ... In contrast PAK1 substrates LIMK-1 or RhoGDI are not likely to contribute to the PAK1 effect on NADPH oxidase activation