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BAX — NPM1
Text-mined interactions from Literome
Lo et al., Hepatology 2013
(Carcinoma, Hepatocellular...) :
Subcellular fractionation revealed that silencing of
NPM expression greatly
enhanced mitochondrial translocation and oligomerization of
BAX in Huh7 and Mahlavu cells
Wang et al., Mol Cell Biol 2013
(Ischemia...) :
Expression of a cytosol restricted NPM mutant ( NPM-dNLS ), but not a nucleus restricted
NPM mutant,
increased NPM-Bax complex formation, mitochondrial NPM and
Bax accumulation, mitochondrial membrane injury, caspase 3 activation, and ischemia induced cell death ... Thus,
NPM-Bax interaction
enhances mitochondrial
Bax accumulation, organelle injury, and cell death