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NRG1 — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ErbB4 signaling events:
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta complex (ERBB4-NRG1)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Elenius et al., Oncogene 1999*, Sweeney et al., J Biol Chem 2000, Cohen et al., J Biol Chem 1996
Evidence: assay, physical interaction
-
Reactome Reaction:
PIK3R1
→
NRG1
(reaction)
Yang et al., J Cell Sci 2007*, Kaushansky et al., Chem Biol 2008, Cohen et al., J Biol Chem 1996
-
Reactome Reaction:
PIK3R1
→
NRG1
(indirect_complex)
Yang et al., J Cell Sci 2007*, Kaushansky et al., Chem Biol 2008, Cohen et al., J Biol Chem 1996
Text-mined interactions from Literome
Chae et al., J Neurophysiol 2005
:
NRG1- and TGF(beta)1 evoked stimulation of K ( Ca ) is
blocked by inhibitors of
PI3K by overexpression of a dominant negative form of Akt, by overexpression of CTMP, an endogenous negative regulator of Akt, and by application of the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate ( HIMO )
Di Segni et al., J Mol Neurosci 2006
:
Taken together, these results indicate that in PC12-ErbB4 cells, the
NRG induced neuroprotective effect from MPP+ treatment, requires
PI3K/PKB/Akt and Ras/MapK signaling networks