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Bernatchez et al., Br J Pharmacol 2001 : 2. Using specific inhibitors and Western blot analysis, we herein report that in bovine aortic endothelial cells ( BAEC ), VEGF induces the synthesis of PAF through the cascade activation of Flk-1 receptor, phospholipase Cgamma ( PLCgamma ), protein kinase C ( PKC ) and p42/44 mitogen activated protein kinases ( MAPK )
Maliba et al., Cell Signal 2006 (MAP Kinase Signaling System) : Angiopoietin mediated endothelial PAF synthesis requires the activation of the p38 and p42/44 MAPKs, PI3K intracellular signalling pathways, and a secreted phospholipase A ( 2 ) ( sPLA ( 2 ) -V )