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MAPK12 — NUP43

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Hu et al., J Pharmacol Exp Ther 1999 : Also, alpha1 receptor stimulation caused a time dependent increase in MAPK activity due to increased phosphorylation of p42/44 ( ERK1/2 )
Singh et al., J Biol Chem 1999 : Cross-talk between these kinases appears to be one-way because modulation of p42/44(MAPK) activity did not affect p38 ( MAPK ) activation by a variety of stress inducers
Smith et al., Nat Med 1999 (Ischemia...) : IGF-1 receptor regulation of VEGF action is mediated at least in part through control of VEGF activation of p44/42 mitogen activated protein kinase , establishing a hierarchical relationship between IGF-1 and VEGF receptors
Van Linden et al., J Biol Chem 2000 : The interaction of tumor necrosis factor-alpha with its receptor CD120a ( p55 ) initiates downstream signaling cascades that include the activation of the mitogen activated protein kinase ( MAPK ), p42 ( mapk/erk2 )
Mackova et al., Endocrinology 2000 : p38MAPK inhibition enhances basal and norepinephrine stimulated p42/44MAPK phosphorylation in rat pinealocytes ... Interaction between p38MAPK and p42/44MAPK in rat pinealocytes was examined by determining the effects of p38MAPK inhibitors on the phosphorylation of p42/44MAPK using Western blot analysis ... Furthermore, inhibition of p42/44MAPK phosphorylation had no effect on p38MAPK activation ... These results suggest that inhibition of p38MAPK causes activation of p42/44MAPK and acts synergistically with norepinephrine in the regulation of p42/44MAPK activation in rat pinealocytes
Nagata et al., Br J Anaesth 2001 : Propofol inhibits FMLP stimulated phosphorylation of p42 mitogen activated protein kinase and chemotaxis in human neutrophils
Utsugi et al., Eur J Pharmacol 2002 : Furthermore, mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ), blocked the lipopolysaccharide induced p44/42 ERK activation and PDGF production
Hatakeyama et al., J Cell Biochem 2002 : We previously reported that prostaglandin F2alpha ( PGF2alpha ) induces phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP binding protein, resulting in the activation of protein kinase C ( PKC ) in osteoblast-like MC3T3-E1 cells and that PGF2alpha stimulates the synthesis of interleukin-6 (IL-6) via PKC dependent p44/p42 mitogen activated protein ( MAP ) kinase activation
Vela et al., Mol Cell Neurosci 2002 : Regarding intracellular signaling, IL-1beta activated the p38 mitogen activated protein kinase ( MAPK ) but not the p42/p44 MAPK and, when combined with growth factors, intensified p38 activation but inhibited the growth-factor induced p42/p44 activation
Kalous et al., Zygote 2003 : The effect of the p42/44 mitogen activated kinase ( MAPK ) inhibitor, PD98059, on MAPK activation and meiosis resumption in mouse oocytes was studied
Xu et al., J Neurosci Res 2003 (MAP Kinase Signaling System) : Estrogen stimulated mouse cortical neurons activate both estrogen response element ( ERE ) stimulated transcription and rapid activation of p44/42 mitogen activated protein kinases ( MAPK )
Man et al., Endocrinology 2004 : We have previously shown that inhibition of p38 ( MAPK ) increases adrenergic stimulated p42/44(MAPK) activation in rat pinealocytes
Cantó et al., J Biol Chem 2004 : HRG also stimulated the activity of p70S6K, p38MAPK , and p42/p44MAPK and inhibition of p42/p44MAPK partially repressed HRG action on glucose uptake
Cvetkovic et al., Brain Res 2004 (Astrocytoma) : The effect of 5-AzadC on astrocyte NO release was blocked by the inhibitor of p44/42 mitogen activated protein kinase dependent signaling
Couty et al., Biol Cell 2004 (Disease Models, Animal...) : In in vitro systems, HHV-8-GPCR signals via multiple transduction pathways including, activation of phospholipase C and PKC, inhibition of adenylyl cyclase, activation of nuclear factor-kappaB ; activation PI 3-kinase, p42/44 MAPK and Akt/PKB, and activation of JNK/SAPK, p38 MAPK and RAFTK
Park et al., J Cell Physiol 2004 : In addition, PD 98059 ( a p44/42 mitogen activated protein kinase ( MAPK ) inhibitor ) but not SB 203580 ( a p38 MAPK inhibitor ) and mepacrine or AACOCF3 ( phospholipase A2 inhibitors ) blocked 25 mM glucose induced inhibition of fructose uptake
Hernandez et al., Diabetologia 2004 (Insulin Resistance) : Since treatment with TNF-alpha activates stress kinases, including c-jun NH2 terminal kinase ( JNK ), and p42/p44 and p38 mitogen activated protein kinases ( MAPK ), we explored the contribution of these pathways to insulin resistance by TNF-alpha
Nkabyo et al., Am J Physiol Gastrointest Liver Physiol 2005 (MAP Kinase Signaling System) : Inhibitors of EGFR ( AG1478 ) and p44/p42 MAPK ( U0126 ) phosphorylation blocked redox dependent p44/p42 phosphorylation, indicating that signaling occurred by EGFR
García-Martínez et al., J Neurosci Res 2006 : GDNF effects on phosphorylated p42/p44 levels were blocked by the mitogen activated protein kinase ( MAPK ) pathway specific inhibitors ( PD98059 and U0126 )
Matsushita et al., Neuroscience 2006 : N-methyl-d-aspartate activated phosphorylation of p44/42 mitogen activated protein kinase and increased expression level of Per1 and Per2 mRNA
Ho et al., Mol Cell Endocrinol 2006 : Studies with selective MAPK inhibitors reveal a modulating effect of MAPKs on arylalkylamine-N-acetyltransferse ( AA-NAT ) activity, with involvement of p42/44MAPK in the induction of AA-NAT and p38MAPK participating in the amplitude and duration of the AA-NAT response
Okada et al., Diabetes 2006 (Albuminuria...) : Pioglitazone suppressed high glucose induced phosphorylation of p44/42 mitogen activated protein kinase and reduced Bcl-2 and p27 ( Kip1 ) protein levels
Morigi et al., Am J Pathol 2006 : We propose a role for p38 and p42/44 mitogen activated protein kinases ( MAPKs ) in mediating NF-kappaB dependent gene transcription induced by Stx-2, based on data that Stx-2 phosphorylated p38 and p42/44 MAPKs and that MAPK inhibitors reduced transcription of NF-kappaB promoter/luciferase reporter gene construct induced by Stx-2
Rivas et al., Exp Cell Res 2008 (Carcinoma, Ductal, Breast...) : A TNF alpha-specific mutein selectively binding to TNFR1 induced p42/p44 MAPK, JNK, Akt activation, NF-kappa B transcriptional activation and cell proliferation, just like wild-type TNF alpha, while a mutein selective for TNFR2 induced only p42/p44 MAPK activation
Jiang et al., Infect Immun 2008 : It was shown that these three proteins could ( i ) induce expression of tumor necrosis factor alpha (TNF-alpha) and tissue factor and ( ii ) induce phosphorylation of p44/42 mitogen activated protein kinases ( MAPK ) and activation of early growth response factor 1 (Egr-1)
Wu et al., Inflamm Res 2008 (Inflammation) : LXA ( 4 ) significantly inhibited LPS stimulated secretion of protein and expressions of mRNA of IL-1beta, IL-6 and IL-8, activation of p38 MAPK , p42/44 MAPK, PI3-K, NF-kappaB and AP-1 but not MyD88 in PMVEC
Park et al., Cell Prolif 2008 (Calcium Signaling) : EGF induced phosphorylation of p38 and p44/42 MAPKs, and this was blocked by SB 203580 ( a p38 MAPK inhibitor ) and PD 98059 ( a p44/42 MAPK inhibitor ), respectively
Ryu et al., J Cell Physiol 2010 (Calcium Signaling) : High glucose induced phosphorylation of protein kinase C ( PKC ), p44/42 mitogen activated protein kinases ( MAPKs ), p38 MAPK , Akt, and mammalian target of rapamycin (mTOR) in a time dependent manner
Montgomery et al., J Biol Chem 1995 (Glioblastoma) : In this report, we document that expression of EGFRvIII in fibroblasts is associated with downstream activation of mitogen activated protein ( MAP ) kinase/extracellular signal regulated kinase ( MEK ) and modest activation of p42 and p44 MAP kinases
Gardner et al., J Biol Chem 1996 : In addition, p42(MAPK) is activated, but a 10-fold greater concentration of TNFalpha was required for substantial MAPK activation than was needed for maximal JNK stimulation
Kinane et al., Am J Physiol 1997 : In predifferentiated LLC-PK1 renal cells, the temporal maximal expression of G alpha(i-2) coincided with maximal activation of MAPK ( p42/p44 ) ... As the known MEKK isoforms ( MEKK1, -2, and -3 ) can also activate SAPKs, these findings suggest the GTP charged G alpha(i-2) subunit transduces growth signals in renal cells via activation of MAPK ( p42/p44 ) and that such activation may be linked to pathways containing novel MEKK isoforms that preferentially activate MEKs
Ushio-Fukai et al., J Biol Chem 1998 : However, exogenous H2O2 activates only p38MAPK ( 14-fold ), and diphenylene iodonium, an NADH/NADPH oxidase inhibitor, attenuates angiotensin II-stimulated phosphorylation of p38MAPK, but not p42/44MAPK
Miyazawa et al., J Biochem 1998 (Arthritis, Rheumatoid) : They have already reached over 150 population doublings through culture crisis, and have been growing rapidly compared with the parental FLSs. Constitutive activation of p42/p44 mitogen activated protein ( MAP ) kinase was detected in MH7A cells