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ODC1 — PIK3R1
Text-mined interactions from Literome
Facchini et al., FEBS Lett 2005
:
In turn Src can activate
PI3K and PKC-delta, and all these signaling proteins are
required for
ODC induction
Wei et al., Am J Physiol Cell Physiol 2008
:
The data illustrated that PD-98059, a MEK ( MAPK kinase ) inhibitor, LY-294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and H-89, a protein kinase A (PKA) inhibitor, substantially decreased the induction of ODC catalytic activity and ODC mRNA expression induced by IL-4 and IL-13, suggesting positive
regulation of the
ODC gene by ERK,
PI3K , and PKA pathways
Flamigni et al., Biochem Biophys Res Commun 1997
(Leukemia L1210) :
These results indicate that
PI3K activity is
required for the induction of
ODC , possibly affecting both ODC mRNA level and translation ... However, LY294002 and wortmannin at concentrations which inhibited almost completely PI3K activity did not decrease p70S6K activity, suggesting that p70S6K does not mediate the
PI3K effects on
ODC , but may lie on a separate pathway in this experimental model