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OLR1 — PPARG
Pathways - manually collected, often from reviews:
-
KEGG PPAR signaling pathway:
Complex of PPARG-RXRA-RXRB-RXRG
→
OLR1
(gene expression, expression)
-
WikiPathways PPAR signaling pathway:
Complex of PPARG-RXRA-RXRG-RXRB
→
SLC27A1/ACSBG2/ACSL6/ACSL3/FABP3/ACSL4/DBI/SLC27A4/CD36/FABP1/ACSL5/ACSL1/OLR1/ACSBG1/LPL
(mim-transcription-translation)
Text-mined interactions from Literome
Chiba et al., Biochem Biophys Res Commun 2001
(Arteriosclerosis) :
PPARgamma ligands
inhibit TNF-alpha induced
LOX-1 expression in cultured endothelial cells ... Taken together,
PPARgamma activators
inhibit TNF-alpha induced
LOX-1 expression in cultured BAEC, which may beneficially influence inflammatory responses in atherosclerosis
Hayashida et al., Ann N Y Acad Sci 2001
:
We therefore explored the
effects of PPARalpha and
PPARgamma ligands on expression of
LOX-1 ...
PPARgamma ligands, in contrast, did not significantly
affect LOX-1 expression in BAECs
Mehta et al., Arterioscler Thromb Vasc Biol 2003
:
The salutary
effect of
PPAR-gamma ligands in atherogenesis may involve the inhibition of
LOX-1 and the adhesion of monocytes to endothelium
Hofnagel et al., Arterioscler Thromb Vasc Biol 2004
(Arteriosclerosis) :
The
PPARgamma activator, 15d-PGJ ( 2 ), however,
inhibited IL-1beta induced upregulation of
LOX-1
Hayashida et al., Biochem Biophys Res Commun 2004
:
PPARalpha-specific ligands, such as fenofibrate and WY-14643, but not
PPARgamma-specific ligands
induced LOX-1 expression
Chui et al., J Clin Invest 2005
(Insulin Resistance) :
OLR1 expression in white adipose tissue is increased in obesity and is further
induced by
PPARgamma ligand treatment in vivo
Takanabe-Mori et al., Biochem Biophys Res Commun 2010
(Disease Models, Animal...) :
LOX-1 expression in adipocytes is
induced by
PPARgamma ( ligands and appears to be involved in adipocyte cholesterol metabolism