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OPN1MW — TNF
Text-mined interactions from Literome
Liou et al., Invest Ophthalmol Vis Sci 2008
:
When the cells or rats were treated with LPS, activation of the A ( 2A ) AR was the most efficient in mediating AR agonist- or
CBD induced
TNF-alpha inhibition
Magen et al., J Hepatol 2009
(Chronic Disease...) :
The
effects of
CBD on cognition, locomotion and on
TNF-alpha receptor 1 expression were blocked by ZM241385, an A ( 2 ) A adenosine receptor antagonist
LIU et al., Acta Pharmacol Sin 2010
(Hypersensitivity, Delayed) :
Histological examination revealed that
CBD suppressed the infiltration of T cells and macrophages, and the expression of interferon ( IFN ) -? and
tumor necrosis factor-a , two pro-inflammatory cytokines implicated in DTH in the inflammatory site
Mukhopadhyay et al., Free Radic Biol Med 2011
(Disease Models, Animal...) :
CBD significantly reduced the extent of liver inflammation, oxidative/nitrative stress, and cell death and also
attenuated the bacterial endotoxin triggered NF-?B activation and
TNF-a production in isolated Kupffer cells, likewise the adhesion molecule expression in primary human liver sinusoidal endothelial cells stimulated with TNF-a and attachment of human neutrophils to the activated endothelium
Karmaus et al., J Immunotoxicol 2013
(Multiple Sclerosis...) :
Concomitantly,
CBD enhanced pro-inflammatory cytokine mRNA production, including
tumor necrosis factor-a (Tnfa) , interleukins (IL)-5 and -23 ( Il6, Il23 ), and granulocyte colony stimulating factor ( Gcsf )