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NOX5 — P4HB
Text-mined interactions from Literome
Wosniak et al., Antioxid Redox Signal 2009
:
Protein disulfide isomerase , an
NADPH oxidase regulator , exhibited increased expression and inverted pattern of migration to membrane fraction after EtBr
Fernandes et al., Arch Biochem Biophys 2009
:
Protein disulfide isomerase overexpression in vascular smooth muscle cells
induces spontaneous preemptive
NADPH oxidase activation and Nox1 mRNA expression : effects of nitrosothiol exposure ... Here, we further investigated
PDI effects on vascular
NADPH oxidase
Santos et al., J Leukoc Biol 2009
(Leishmaniasis) :
PDI , a redox chaperone, is
involved in host cell uptake of bacteria/viruses, phagosome formation, and vascular
NADPH oxidase regulation
Laurindo et al., Free Radic Biol Med 2012
:
PDI overexpression spontaneously
enhances Nox activation and expression
Jaronen et al., Hum Mol Genet 2013
(Amyotrophic Lateral Sclerosis) :
Because mutant SOD1 can cause sustained activation of NADPH oxidase ( NOX ), we investigated the
role of
PDI in UPR induced
NOX activation in microglia ... Importantly, pharmacological inhibition of
PDI or its down-regulation by short interfering RNAs
prevented NOX activation in microglia and subsequent production of superoxide ... Thus, results strongly demonstrate that UPR, caused by protein misfolding, may lead to
PDI dependent
NOX activation and contribute to neurotoxicity in neurodegenerative diseases including ALS