Linnemann et al., Virology 2002
:
Finally, inhibition of PI3K blocked the activation of PAK and decreased the production of viral particles to levels observed with the Nef deleted provirus
Wilkes et al., Cancer Res 2005
:
PI3K activation occurs in the presence of dominant negative dynamin and is required for p21 activated kinase-2 kinase activity and the increased proliferation and morphologic change induced by TGF-beta in vitro
Chan et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
PAK is regulated by PI3K , PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress induced p38 pathway