UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

IL6 — PARP1

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: IL6 → PARP1 (increases) Piconi et al., Journal of thrombosis and haemostasis : JTH 2004 *
Evidence: Pharmacological inhibition of PARP suppressed both nitrotyrosine formation, adhesion molecule expression and IL-6 to the levels seen in the normal glucose conditions.

Text-mined interactions from Literome

Piconi et al., Journal of thrombosis and haemostasis : JTH 2004 (Inflammation) : Pharmacological inhibition of PARP suppressed both nitrotyrosine formation, adhesion molecule expression and IL-6 to the levels seen in the normal glucose conditions
Kaplin et al., J Clin Invest 2005 (Inflammation...) : IL-6 was necessary and sufficient to mediate cellular injury in spinal cord organotypic tissue culture sections through activation of the JAK/STAT pathway, resulting in increased activity of iNOS and poly ( ADP-ribose ) polymerase ( PARP )
Huang et al., Mediators Inflamm 2009 (MAP Kinase Signaling System) : Upregulation of Salmonella induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB ... Upregulation of Salmonella induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB