Shu et al., Mol Cell Biol 2002
(Carcinoma...) :
Inhibition of SPK by pharmacological inhibitors, a dominant negative SPK mutant, or siRNA that targets SPK blocked VEGF, but not EGF, induction of phospho-ERK1/2 Duan et al., Exp Cell Res 2004
:
It is suggested that PI3K and ERK/MAPK mediated the activation of SPK and would be involved in the HGF induced migration of endothelial cells
Yadav et al., J Immunol 2006
(Mycobacterium Infections) :
In the present work we found that SPK is required for ERK1/2 activation in murine macrophages infected with either M. avium or M. smegmatis
Aksamitiene et al., Cell Signal 2010
(Breast Neoplasms...) :
We discuss candidate proteins that can be involved in this activation circuitry and suggest that PDZ Binding Kinase/T-LAK Cell Originated Protein Kinase ( PBK/TOPK ) may play a role in mediating MEK independent ERK activation